Methyl iodide → HCID 58014019、化合物
反応式
I[CH3:2].[Si:3]([O:10][CH2:11][C:12]1[C:13]2[N:14]([N:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=2)[C:15]([CH2:18][OH:19])=[CH:16][CH:17]=1)([C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:5])[CH3:4]>C(#N)C.[Ag]=O>[Si:3]([O:10][CH2:11][C:12]1[C:13]2[N:14]([N:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=2)[C:15]([CH2:18][O:19][CH3:2])=[CH:16][CH:17]=1)([C:6]([CH3:9])([CH3:7])[CH3:8])([CH3:5])[CH3:4]参加物
5
実験手順
Silver oxide (30.0 g) and iodomethane (16.1 mL) were added to a solution of the compound of Example 324 (9.53 g) in acetonitrile (300 mL). The mixture was stirred at room temperature for 85 hours. Subsequently, the mixture was filtered through Celite. The filtrate was concentrated and purified by silica gel column chromatography (hexane:ethyl acetate=15:1) to afford the title compound as a pale yellow powder (8.76 g).