Sulfuric Acid → 5-Amino-2-methoxybenzoic acid
反応式
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[C:17](=O)([O-])[O-].[Na+].[Na+]>CO>[CH3:17][O:11][C:5]1[C:6](=[CH:10][C:2]([NH2:1])=[CH:3][CH:4]=1)[C:7]([OH:9])=[O:8]参加物
5
実験手順
A solution of 10 g of 5-aminosalicyclic acid, 100 ml of methanol and 5 ml of sulfuric acid are refluxed overnight. The reaction mixture is cooled, basified with sodium carbonate and the methanol is evaporated. The resulting solid is washed with water and dried giving 4.0 g of methyl-5-aminosalicylic acid.
後処理
- temperatureThe reaction mixture is cooled
- customthe methanol is evaporated
- washThe resulting solid is washed with water
- customdried
出典と根拠
- ORDレコード
- ord-0bc782b352414c98ba5f6e110eaba258
- 出典データセット
- uspto-grants-1979_06
- 特許番号
- US04159384
反応ノート
読み込み中…