Methyl iodide → HCID 18979095、化合物

HRID 2393095ノート

反応式

HRID 2393095 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[N:7]2.O1CCC[CH2:23]1.[H-].[Na+].IC>C(OCC)(=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([N:14]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH3:23])=[N:7]2

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 18979069HCID 18979069、化合物

生成物 1

HCID 18979095HCID 18979095、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

5-Bromo-2-t-butyloxycarbonylamino-8-Methoxyquinoline (1.21 g) and tetrahydrofuran (20 ml) were combined at room temperature under a nitrogen atmosphere. Sodium hydride (60% dispersion in oil) (164 mg) was added and the reaction mixture stirred for 2 h whilst effervescence occurred and a yellow colour appeared. Iodomethane (0.43 ml) was then added and stirring was continued for 2 h after which time the reaction was diluted with ethyl acetate (100 ml), washed successively with water, saturated aqueous sodium bicarbonate and brine, then dried (magnesium sulphate) and evaporated in vacuo to give the title compound (1.1 g) as a yellow solid.

後処理

  1. customwere combined at room temperature under a nitrogen atmosphere
  2. stirringstirring
  3. waitwas continued for 2 h
  4. washwashed successively with water, saturated aqueous sodium bicarbonate and brine
  5. dry with materialdried (magnesium sulphate)
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-8da48e0f22ce4333aa4ab2cfb937ba4a
出典データセット
uspto-grants-1998_09
特許番号
US05804588

反応ノート

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