Pyridine → HCID 18973686、化合物

HRID 2399413ノート

反応式

HRID 2399413 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9]O)[CH2:3][CH2:2]1.N1C=CC=CC=1.S(Cl)([Cl:26])=O>C(Cl)(Cl)Cl>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9][Cl:26])[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 54527366HCID 54527366、化合物

生成物 1

HCID 18973686HCID 18973686、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of crude 3-cyclopropylmethoxy-4-difluoromethoxybenzyl alcohol (24.4 g) and pyridine (9.8 mL, 120 mmol) in chloroform (150 mL) under an argon atmosphere was treated with thionyl chloride (8.0 mL, 110 mmol) and the mixture was heated at reflux for 1 h. The solvent was removed, ether was added and the precipitate was removed by filtration. The filtrate was concentrated to a pale yellow oil (26 g).

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 1 h
  3. customThe solvent was removed
  4. additionether was added
  5. customthe precipitate was removed by filtration
  6. concentrationThe filtrate was concentrated to a pale yellow oil (26 g)

出典と根拠

ORDレコード
ord-dc50575213254386a18d973dcacb78df
出典データセット
uspto-grants-1995_09
特許番号
US05449686

反応ノート

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