Pyridine → Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester

HRID 2401258ノート

反応式

HRID 2401258 の反応式
N1C=CC=CC=1.[F:7][C:8]([F:17])([F:16])[C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][N:10]=1.Cl[C:19]([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:20]>C(Cl)(Cl)Cl>[C:22]1([O:21][C:19](=[O:20])[NH:15][C:12]2[CH:11]=[N:10][C:9]([C:8]([F:7])([F:16])[F:17])=[CH:14][CH:13]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 27377445-Amino-2-(trifluoromethyl)pyridine

生成物 1

HCID 11173582Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Pyridine (2.9 mL) was added to a solution of 2-trifluoromethyl-5-aminopyridine (1.95 g) in chloroform (15 mL), the mixture was cooled in ice, and phenyl chloroformate (1.8 mL) was added thereto. The resulting mixture was stirred at room temperature overnight, and the reaction mixture was concentrated under reduced pressure. The residue was washed with isopropyl ether to afford phenyl[6-(trifluoromethyl)pyridin-3-yl]carbamate (2.16 g).

後処理

  1. temperaturethe mixture was cooled in ice
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. washThe residue was washed with isopropyl ether

出典と根拠

ORDレコード
ord-5d1832adacc84cc5a9b528ac0e14cb03
出典データセット
uspto-grants-2014_08
特許番号
US08796272B2

反応ノート

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