4-Nitro-1H-indole → 4-Aminoindole

HRID 240468

反応式

HRID 240468 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2)([O-])=O.[H][H]>[Pd].C1COCC1>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2

参加物

5

反応物 2

HCID 1457664-Nitro-1H-indoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 5834314-Aminoindole

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A round-bottom flask was charged with 4-nitroindole (4.8 g, 30 mmol), Palladium on carbon (10%, 480 mg), and THF (50 mL), and the mixture was stirred under one hydrogen atmosphere overnight. TLC showed the reaction was complete. The catalyst was filtered off and the filtrate was concentrated to afford 4-amino-1H-indole, which was used directly in the next step without purification.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-c9141032da62429ea72e176f8ff59e25
出典データセット
uspto-grants-2014_02
特許番号
US08648086B2

関連ノート

読み込み中…