Tetrahydrothiophene → Phenacyltetrahydrothiophenium bromide

HRID 24964

反応式

HRID 24964 の反応式
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:6]([Br:15])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]>C(#N)C>[Br-:15].[CH2:6]([S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

参加物

4

反応物 2

HCID 1127TetrahydrothiopheneHCID 6259Phenacyl bromide

生成物 1

HCID 11346720Phenacyltetrahydrothiophenium bromide収率 94.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

Tetrahydrothiophene (53.2 g) was dissolved in 400 ml of acetonitrile, and thereto was slowly added a solution obtained by dissolving 100 g of phenacyl bromide in 300 ml of acetonitrile, and the solution was stirred at room temperature for 3 hours, thereby a powder was precipitated. The reaction solution was poured into 1,500 ml of ethyl acetate, and the powder was filtered out and dried, thus 137 g of phenacyltetrahydrothiophenium bromide was obtained.

後処理

  1. additionwas slowly added a solution
  2. customobtained
  3. customa powder was precipitated
  4. additionThe reaction solution was poured into 1,500 ml of ethyl acetate
  5. filtrationthe powder was filtered out
  6. customdried

出典と根拠

ORDレコード
ord-92317603e81c4877acde22e58de207d2
出典データセット
uspto-grants-2005_02
特許番号
US06858370B2

関連ノート

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