Sodium Iodide → 3-Hydroxy-4-iodobenzoic acid

HRID 250915

反応式

HRID 250915 の反応式
[OH-].[Na+].[I-:3].[Na+].[OH:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9]([OH:11])=[O:10].Cl[O-].[K+]>CO>[OH:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[I:3])[C:9]([OH:11])=[O:10]

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 74203-Hydroxybenzoic AcidHCID 14798Sodium HydroxideHCID 23665762Potassium hypochlorite

生成物 1

HCID 7368543-Hydroxy-4-iodobenzoic acid収率 92%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

21.0 g (0.52 mol, 1.05 eq) of sodium hydroxide and then 78.7 g (0.52 mol, 1.05 eq) of sodium iodide are added to a solution of 69.1 g (0.5 mol, 1 eq) of 3-hydroxybenzoic acid in 700 ml of methanol. The reaction mixture is cooled to 0° C. and potassium hypochlorite solution (0.52 mol, 1.05 eq) is then added dropwise. The reaction medium is stirred at 0-5° C. for 2 hours and then at room temperature overnight. The methanol is evaporated off and the reaction medium is then acidified with concentrated hydrochloric acid solution. The precipitated product is filtered off, washed with water and dried. 121 g of 3-hydroxy-4-iodobenzoic acid are obtained in the form of an off-white solid. Yield=92%

後処理

  1. customat room temperature
  2. customovernight
  3. customThe methanol is evaporated off
  4. filtrationThe precipitated product is filtered off
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-8659b4409d0a4f239d22195facf37b3e
出典データセット
uspto-grants-2011_01
特許番号
US07863332B2

関連ノート

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