反応式
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:17]([OH:19])=O)[CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[C:21]1[C:29]2N=NN[C:25]=2[CH:24]=[CH:23][CH:22]=1.Cl.[CH3:31]N(C)CCCN=C=NCC.[NH2:42][CH2:43][CH2:44][CH:45]([O:49][CH2:50][CH3:51])[O:46][CH2:47][CH3:48].C(N(CC)C(C)C)(C)C>O1CCCC1>[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:17]([NH:42][CH2:43][CH2:44][CH:45]([O:49][CH2:50][CH3:51])[O:46][CH2:47][CH3:48])=[O:19])[CH2:13][C:14]([O:16][CH2:31][C:21]1[CH:29]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:15])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
7
反応物 5
生成物 1
試薬・触媒・溶媒 1
実験手順
By using an analogous procedure to that described for Reference Example 13, benzyloxycarbonyl-L-aspartic acid [1-benzyl ester (2 g, 5.6 mmol), hydroxybenzotriazole (756 mg, 5.6 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.07 g, 5.6 mmol), 1-amino-3,3-diethoxypropane (784 mg, 5.3 mmol) and N,N-diisopropylethylamine (0.986 mL, 5.6 mmol) were reacted in anhydrous tetrahydrofuran (30 ml) at room temperature for 16 hours, to provide benzyl (3S)-3-{[(benzyloxy)carbonyl]amino}-4-[(3,3-diethoxypropyl)amino]-4-oxobutanoate (2.81 g, 100%) as a pale yellow waxy solid.
出典と根拠
- ORDレコード
- ord-d96b4e3070854d9da39bcc7490a10a3a
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06858591B2
関連ノート
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