1-Dodecanethiol → 1-(n-Dodecylthio)-3-isopropoxy-2-propanol

HRID 259267

反応式

HRID 259267 の反応式
[CH:1]([O:4][CH2:5][CH:6]1[O:8][CH2:7]1)([CH3:3])[CH3:2].[H-].[Na+].[CH3:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][SH:23]>O1CCCC1>[CH2:22]([S:23][CH2:7][CH:6]([OH:8])[CH2:5][O:4][CH:1]([CH3:2])[CH3:3])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH3:11]

参加物

5

反応物 3

HCID 81951-DodecanethiolHCID 199202-((1-Methylethoxy)methyl)oxiraneHCID 24758Sodium hydride

生成物 1

HCID 214239641-(n-Dodecylthio)-3-isopropoxy-2-propanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
60 °C

実験手順

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

後処理

  1. customformed by the addition of 50 mg
  2. customAfter approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
  3. additionof water is added to the residue
  4. extractionThe resultant aqueous mixture is extracted with ether
  5. washthe ether extracts washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-1f4109b6444941dcb8d0392730d445b1
出典データセット
uspto-grants-1977_07
特許番号
US04036974

関連ノート

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