1,3-Dibromo-2-propanol → 1,3-Bis(benzylthio)-2-propanol

HRID 259273ノート

反応式

HRID 259273 の反応式
Br[CH2:2][CH:3]([OH:6])[CH2:4]Br.[CH2:7]([SH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[H-].[Na+]>O1CCCC1>[CH2:7]([S:14][CH2:2][CH:3]([OH:6])[CH2:4][S:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 72871,3-Dibromo-2-propanolHCID 7509Benzyl mercaptanHCID 24758Sodium hydride

生成物 1

HCID 158896411,3-Bis(benzylthio)-2-propanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1,3-dibromo-2-propanol (2.18 g.) is added to a stirred suspension of the salt obtained by mixing 2.7 g. benzyl mercaptan and sodium hydride (56% dispersion in mineral oil; 900 mg.) in 50 ml. dry tetrahydrofuran. After 2 hours at room temperature, the solvent is removed and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the extracts washed with water, dried over magnesium sulfate and evaporated to yield 1,3-bis(benzylthio)-2-propanol.

後処理

  1. customobtained
  2. additionby mixing 2.7 g
  3. customthe solvent is removed
  4. additionof water is added to the residue
  5. extractionThe resultant aqueous mixture is extracted with ether
  6. washthe extracts washed with water
  7. dry with materialdried over magnesium sulfate
  8. customevaporated

出典と根拠

ORDレコード
ord-536ea60cb1c54306a8415c4d5b8a0e4e
出典データセット
uspto-grants-1977_07
特許番号
US04036970

反応ノート

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