Water → HCID 178511480、化合物

HRID 26158

反応式

HRID 26158 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C:12]#[N:13])(=O)=[O:9])=[CH:4][CH:3]=1.[ClH:14].[NH2:15][OH:16].[OH2:17].C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[Cl:14][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH2:11][C:12](=[NH:13])[NH:15][OH:16])(=[O:9])=[O:17])=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 7358292-(4-Chlorobenzenesulfonyl)acetonitrile

生成物 1

HCID 178511480HCID 178511480、化合物収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

50 g. (0.23 mole) of 4-chlorophenylsulfonylacetonitrile were dissolved in 1.5 liters of ethanol and 16 g. (0.23 mole) of hydroxylamine HCl in 150 ml. of water was added to this solution, followed by the addition of 14.4 g. (0.12 mole) of Na2CO3 in 150 ml. of water. This reaction mixture was stirred at room temperature overnight. 58 g. crude product were filtered off; this was recrystallized from about 2.5 liters of ethanol to give 40 g. of the product (70% yield).

後処理

  1. additionfollowed by the addition of 14.4 g
  2. filtrationcrude product were filtered off
  3. customthis was recrystallized from about 2.5 liters of ethanol
  4. customto give 40 g

出典と根拠

ORDレコード
ord-cfb04106ce044c1b82b83425a88a2633
出典データセット
uspto-grants-1979_04
特許番号
US04148801

関連ノート

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