Hydrochloric Acid → 4-Chlorophenyl Isocyanate

HRID 262065

反応式

HRID 262065 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](N)=[O:10])=[CH:4][CH:3]=1.N([O-])=O.[Na+].Cl.C(Cl)(Cl)Cl>O.F[B-](F)(F)F.C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 87964-ChlorophenylureaHCID 23668193Sodium Nitrite

生成物 1

HCID 76934-Chlorophenyl Isocyanate

試薬・触媒・溶媒 2

HCID 67932Tetrabutylammonium Tetrafluoroborate触媒HCID 962Water溶媒

実験手順

4-Chlorophenyl urea (8.5 parts) and a solution of sodium nitrite (6.9 parts) in water (10 parts) were added over 6 hours to a mixture of conc. hydrochloric acid (10.3 parts) chloroform (130 parts) and tetra-n-butyl ammonium fluoroborate (10% by weight based on 4-chlorophenyl urea) at -10° to -5° C. The mixture was stirred for a further 15 minutes then the stirrer stopped and layers allowed to separate. No solid was present at this stage. 5 mls of the organic layer was taken for analysis and the remainder kept cold until required.

後処理

  1. customto separate

出典と根拠

ORDレコード
ord-b62cc6b7e3f94970b45c84cfc794cd41
出典データセット
uspto-grants-1979_05
特許番号
US04153624

関連ノート

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