Ammonia → 2-Methoxyphenyl-4-methylcyclohexanone
反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[NH2-].[Na+].Cl[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].N>O1CCCC1>[CH3:19][O:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH:4]1[CH2:3][CH:2]([CH3:1])[CH2:7][CH2:6][C:5]1=[O:8]参加物
6
実験手順
4-Methylcyclohexanone (224 g, 2 moles) was added dropwise rapidly to a cooled, stirred suspension of 170 g (4 moles) of sodium amide in 2 l of tetrahydrofuran under nitrogen. After the addition was complete, the ice bath was removed and the mixture was heated at reflux until the evolution of ammonia ceased (~3 hours). While still at reflux, 142.5 g (1 mole) of o-chloroanisole was added rapidly dropwise and the mixture was heated for an additional hour, until evolution of ammonia ceased.
後処理
- additionAfter the addition
- customthe ice bath was removed
- temperaturethe mixture was heated
- temperatureat reflux until the evolution of ammonia
- custom(~3 hours)
- temperatureWhile still at reflux
出典と根拠
- ORDレコード
- ord-fac347d6f8b34305bb034a27a9abc60b
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04150135
反応ノート
読み込み中…