Ammonia → 2-Methoxyphenyl-4-methylcyclohexanone

HRID 26482

反応式

HRID 26482 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[NH2-].[Na+].Cl[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].N>O1CCCC1>[CH3:19][O:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH:4]1[CH2:3][CH:2]([CH3:1])[CH2:7][CH2:6][C:5]1=[O:8]

参加物

6

反応物 4

HCID 222AmmoniaHCID 115254-MethylcyclohexanoneHCID 130112-ChloroanisoleHCID 24533Sodium amide

生成物 1

HCID 213232862-Methoxyphenyl-4-methylcyclohexanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-Methylcyclohexanone (224 g, 2 moles) was added dropwise rapidly to a cooled, stirred suspension of 170 g (4 moles) of sodium amide in 2 l of tetrahydrofuran under nitrogen. After the addition was complete, the ice bath was removed and the mixture was heated at reflux until the evolution of ammonia ceased (~3 hours). While still at reflux, 142.5 g (1 mole) of o-chloroanisole was added rapidly dropwise and the mixture was heated for an additional hour, until evolution of ammonia ceased.

後処理

  1. additionAfter the addition
  2. customthe ice bath was removed
  3. temperaturethe mixture was heated
  4. temperatureat reflux until the evolution of ammonia
  5. custom(~3 hours)
  6. temperatureWhile still at reflux

出典と根拠

ORDレコード
ord-fac347d6f8b34305bb034a27a9abc60b
出典データセット
uspto-grants-1979_04
特許番号
US04150135

関連ノート

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