Hydrogen Bromide → 2-Bromo-1-(1-naphthalenyl)ethanone

HRID 26539

反応式

HRID 26539 の反応式
[C:1]1([C:11]([CH3:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(Cl)(Cl)Cl.[BrH:18]>[Cu](Br)Br.C(OCC)(=O)C>[C:1]1([C:11]([CH2:13][Br:18])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 260Hydrogen BromideHCID 6212ChloroformHCID 136631-Acetylnaphthalene

生成物 1

HCID 38305132-Bromo-1-(1-naphthalenyl)ethanone

試薬・触媒・溶媒 2

HCID 24611Copper bromide (CuBr2)触媒HCID 8857Ethyl Acetate溶媒

実験手順

Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.

後処理

  1. additionis treated with 26.5 g
  2. customThe resulting reaction mixture
  3. temperatureis heated
  4. temperatureunder reflux
  5. customis removed
  6. additionether is added
  7. customthe copper (I) bromide is removed by filtration
  8. customEvaporation of the filtrate under reduced pressure

出典と根拠

ORDレコード
ord-1489e7152d2f4faab50106df544efc62
出典データセット
uspto-grants-1979_04
特許番号
US04150153

関連ノート

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