Hydrogen Bromide → 2-Bromo-1-(1-naphthalenyl)ethanone
反応式
[C:1]1([C:11]([CH3:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(Cl)(Cl)Cl.[BrH:18]>[Cu](Br)Br.C(OCC)(=O)C>[C:1]1([C:11]([CH2:13][Br:18])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1参加物
6
実験手順
Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.
後処理
- additionis treated with 26.5 g
- customThe resulting reaction mixture
- temperatureis heated
- temperatureunder reflux
- customis removed
- additionether is added
- customthe copper (I) bromide is removed by filtration
- customEvaporation of the filtrate under reduced pressure
出典と根拠
- ORDレコード
- ord-1489e7152d2f4faab50106df544efc62
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04150153
反応ノート
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