Dimethylcarbamoyl Chloride → alpha-Diethylcarbamylthio-2'-chloro-4-biphenylylacetic acid

HRID 267397

反応式

HRID 267397 の反応式
[CH2:1]([N:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].C(Cl)(=O)N.C(NC(Cl)=O)C.CN(C)C(Cl)=O.C([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[Cl:45])=[CH:35][CH:34]=1)[C:30]([OH:32])=[O:31])(=O)N.C(NC(SC(C1C=CC(C2C=CC=CC=2Cl)=CC=1)C(O)=O)=O)C.CN(C)C(SC(C1C=CC(C2C=CC=CC=2Cl)=CC=1)C(O)=O)=O>>[CH2:1]([N:3]([CH2:7][CH3:8])[C:4]([S:28][CH:29]([C:33]1[CH:38]=[CH:37][C:36]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[Cl:45])=[CH:35][CH:34]=1)[C:30]([OH:32])=[O:31])=[O:5])[CH3:2]

参加物

8

反応物 7

HCID 6598Dimethylcarbamoyl ChlorideHCID 6916Diethylcarbamoyl chlorideHCID 68048Carbamic chlorideHCID 12321963N-ethylcarbamoyl chlorideHCID 21556048alpha-Carbamylthio2'-chloro-4-biphenylylacetic acidHCID 21556323alpha-Dimethylcarbamylthio-2'-chloro-4-biphenylylacetic acidHCID 54353825alpha-Ethylcarbamylthio-2'-chloro-4-biphenylylacetic acid

生成物 1

HCID 21556371alpha-Diethylcarbamylthio-2'-chloro-4-biphenylylacetic acid

実験手順

When diethylcarbamylchloride is replaced in the above procedure by carbamyl chloride (prepared in situ from potassium cyanate and anhydrous hydrogen chloride in anhydrous chloroform), ethylcarbamyl chloride or dimethylcarbamyl chloride, then the products prepared are α-carbamylthio2'-chloro-4-biphenylylacetic acid, α-ethylcarbamylthio-2'-chloro-4-biphenylylacetic acid or α-dimethylcarbamylthio-2'-chloro-4-biphenylylacetic acid.

後処理

  1. customthe products prepared

出典と根拠

ORDレコード
ord-92812363b4e14ecfb4da9e08a1558a01
出典データセット
uspto-grants-1976_03
特許番号
US03941821

関連ノート

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