Pyridine → 3-acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin

HRID 267776ノート

反応式

HRID 267776 の反応式
[C:1]([O:4][C:5]1([CH2:17][N:18]([CH:22]([CH3:24])[CH3:23])[C:19](=[O:21])[CH3:20])[CH2:11][O:10][C:9]2[CH:12]=[CH:13][C:14]([NH2:16])=[CH:15][C:8]=2[O:7][CH2:6]1)(=[O:3])[CH3:2].Cl[C:26]([O:28][CH2:29][CH3:30])=[O:27].N1C=CC=CC=1>C(Cl)(Cl)Cl.O>[C:1]([O:4][C:5]1([CH2:17][N:18]([CH:22]([CH3:24])[CH3:23])[C:19](=[O:21])[CH3:20])[CH2:11][O:10][C:9]2[CH:12]=[CH:13][C:14]([NH:16][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:15][C:8]=2[O:7][CH2:6]1)(=[O:3])[CH3:2]

参加物

6

反応物 3

HCID 1049PyridineHCID 10928Ethyl chloroformateHCID 540731773-acetoxy-3-(N-acetylisopropylaminomethyl)-7-amino-3,4-dihydro-2H-1,5-benzodioxepin

生成物 1

HCID 538213713-acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6212Chloroform溶媒2 回

実験手順

3-Acetoxy-3-N-acetylisopropylaminomethyl-7-amino-3,4-dihydro-2H-1,5-benzodioxepin (0.1 mole) from Example 86, Step B, in chloroform is treated with 0.11 mole of ethyl chloroformate and pyridine in chloroform. The mixture after stirring and heating in a water bath for several hours is diluted with water, extracted with ether, the combined ethereal extracts washed, dried and evaporated to give 3-acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin.

後処理

  1. temperatureheating in a water bath for several hours
  2. extractionextracted with ether
  3. washthe combined ethereal extracts washed
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-6c8803a3d3b2481dac31f188b3ca1da3
出典データセット
uspto-grants-1976_03
特許番号
US03944560

反応ノート

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