Methyl iodide → Ethyl 2-methylacetoacetate

HRID 268505

反応式

HRID 268505 の反応式
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[C:10]([CH:15]1[CH2:19]C[CH2:17][C:16]1=[O:20])([O:12][CH2:13][CH3:14])=[O:11].[C:21]([CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])(=[O:28])[C:22]1[CH:27]=[CH:26]C=CC=1.[CH3:35][C:36]1[CH:49]=CC=C[C:37]=1[C:38]([CH2:40][C:41](OCC)=O)=O.CI>>[CH3:19][CH:15]([C:16]([CH3:17])=[O:20])[C:10]([O:12][CH2:13][CH3:14])=[O:11].[CH3:1][C:29]1([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:26][CH2:27][CH2:22][C:21]1=[O:28].[CH3:35][C:36]1([CH3:49])[CH:37]=[CH:38][CH:40]=[CH:41][CH:5]1[C:3]([CH2:2][C:1]([O:7][CH2:8][CH3:9])=[O:6])=[O:4]

参加物

8

反応物 5

HCID 6328Methyl iodideHCID 7170Ethyl benzoylacetateHCID 8868Ethyl AcetoacetateHCID 69136Ethyl 2-oxocyclopentanecarboxylateHCID 2760276Ethyl 2-methyl-beta-oxobenzenepropanoate

生成物 3

HCID 701Ethyl 2-methylacetoacetateHCID 227353Ethyl 1-methyl-2-oxocyclopentane-1-carboxylateHCID 68118422Ethyl 2,2-dimethylbenzoylacetate

実験手順

When the thallous salts of ethyl acetoacetate, 2-carbethoxycyclopentanone, ethyl benzoylacetate, and ethyl 2-methylbenzoylacetate, prepared according to Example 1, are refluxed with methyl iodide as described in Example 1 for periods of about 4, 9, 4, and 14 hours, respectively, ethyl 2-methylacetoacetate (b.p. 82°/25 mm.), 2-methyl- 2-carbethoxy-cyclopentanone (b.p. 124°-126°/35 mm.), ethyl 2-methylbenzoyl acetate (b.p. 96°-97°/0.25 mm.), and ethyl 2,2-dimethylbenzoyl-acetate (b.p. 98°-100°/0.35 mm.), respectively, are obtained in quantitative yield.

出典と根拠

ORDレコード
ord-25422b156e2344fcb6334b2a06b491e6
出典データセット
uspto-grants-1976_03
特許番号
US03947488

関連ノート

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