反応式
Cl[CH2:2][C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1.[Na].[CH2:10]([OH:13])[CH2:11][OH:12]>>[OH:12][CH2:11][CH2:10][O:13][CH2:2][C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1参加物
4
実験手順
2-Chloromethylpyrazine is reacted with the sodium salt of ethylene glycol to give 2-(2-hydroxyethoxymethyl)pyrazine which is treated with thionyl chloride to give 2-(2-chloroethoxymethyl)pyrazine. Using this intermediate in place of 4-(3-chloropropoxy(methylimidazole in the procedure of Example 22 gives the title compound.
出典と根拠
- ORDレコード
- ord-738a1d3057c54f41b9c4d43bb5ae35b6
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04221802
関連ノート
読み込み中…