Succinic anhydride → Thyroxine

HRID 279819

反応式

HRID 279819 の反応式
O1CCCC1.C(N(CC)CC)C.C1(=O)OC(=O)CC1.Cl.C[O:22][C:23](=[O:45])[C@H:24]([CH2:26][C:27]1[CH:34]=[C:32]([I:33])[C:31]([O:35][C:36]2[CH:43]=[C:41]([I:42])[C:40]([OH:44])=[C:38]([I:39])[CH:37]=2)=[C:29]([I:30])[CH:28]=1)[NH2:25]>>[NH2:25][C@H:24]([C:23]([OH:45])=[O:22])[CH2:26][C:27]1[CH:28]=[C:29]([I:30])[C:31]([O:35][C:36]2[CH:37]=[C:38]([I:39])[C:40]([OH:44])=[C:41]([I:42])[CH:43]=2)=[C:32]([I:33])[CH:34]=1

参加物

5

反応物 4

HCID 7922Succinic anhydrideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 13911220Methyl thyroxinate hydrochloride

生成物 1

HCID 5819Thyroxine

反応条件

温度
4 °C

実験手順

In 150 ml of dried tetrahydrofuran 1.65 g (0.002 mol) of thyroxine methyl ester hydrochloride was dissolved. To the resulting solution 300 μl (0.0021 mol) of triethyl amine and 200 mg. (0.0022 mol) of succinic anhydride were added. The mixture was stirred at 4° C. overnight to effect reaction.

後処理

  1. customreaction

出典と根拠

ORDレコード
ord-d6e33fbb8e70494a89adc8bd3b8100b1
出典データセット
uspto-grants-1986_05
特許番号
US04587102

関連ノート

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