Water → 3-(4-Methylphenyl)propan-1-amine
反応式
C[C:2]1C=C[C:5]([CH:8](C)[C:9]([NH2:11])=O)=[CH:4][CH:3]=1.[Li].O.[OH-].[Na+].O1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH3:18][C:19]1[CH:2]=[CH:3][C:4]([CH2:5][CH2:8][CH2:9][NH2:11])=[CH:21][CH:20]=1参加物
6
実験手順
2-(4-Methylphenyl)propionamide (4 g) in dry tetrahydrofuran was added dropwise under nitrogen to lithium alumimium hydride (0.93 g) in dry tetrahydrofuran. The mixture was refluxed for 1 h at the end of addition. Water (1 ml), 2N. NaOH (1 ml), further water (3 ml) were added, the mixture filtered and the filtrate evaporated to give 3-(4-methylphenyl)propanamine (3.5 g).
後処理
- temperatureThe mixture was refluxed for 1 h at the end of addition
- filtrationthe mixture filtered
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-df22234db89d499b8b5fcdf34a6d839c
- 出典データセット
- uspto-grants-1986_05
- 特許番号
- US04588749
反応ノート
読み込み中…