Diethyl Malonate → HCID 178418389、化合物
反応式
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[NH:5][C:4]([CH3:10])(N)[N:3]=1.[O-]CC.[Na+].[Na].Cl.C(N)(=N)C.C(OCC)(=O)CC(OCC)=O>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH3:10])[N:3]=1参加物
7
実験手順
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.
後処理
- temperaturethe reaction mixture heated
出典と根拠
- ORDレコード
- ord-4d14267579d347aaab5da8765031fa8d
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05732717
反応ノート
読み込み中…