Diethyl Malonate → HCID 178418389、化合物

HRID 3046

反応式

HRID 3046 の反応式
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[NH:5][C:4]([CH3:10])(N)[N:3]=1.[O-]CC.[Na+].[Na].Cl.C(N)(=N)C.C(OCC)(=O)CC(OCC)=O>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH3:10])[N:3]=1

参加物

7

反応物 5

HCID 7761Diethyl MalonateHCID 67170Acetamidine monohydrochlorideHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 1784183454,6-Dihydroxy-2-methylpyrimidinamine

生成物 1

HCID 178418389HCID 178418389、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.

後処理

  1. temperaturethe reaction mixture heated

出典と根拠

ORDレコード
ord-4d14267579d347aaab5da8765031fa8d
出典データセット
uspto-grants-1998_03
特許番号
US05732717

関連ノート

読み込み中…