Toluene → 2-Benzyloxy-6-bromopyridine

HRID 322063

反応式

HRID 322063 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[OH-:9].[K+].[C:11]1([CH3:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1OCCOCCOCCOCCOCCOC1>[CH2:17]([O:9][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 122742,6-DibromopyridineHCID 14797Potassium Hydroxide

生成物 1

HCID 8174752-Benzyloxy-6-bromopyridine

試薬・触媒・溶媒 1

HCID 2855718-Crown-6触媒

実験手順

A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.

後処理

  1. temperatureunder reflux for 30 minutes
  2. washThe cool solution washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customto give an oil which
  6. distillationis vacuum-distilled (Kugelrohr)

出典と根拠

ORDレコード
ord-93682894d27b42bb9ad767ec95113533
出典データセット
uspto-grants-2001_04
特許番号
US06211220B1

関連ノート

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