Toluene → 2-Benzyloxy-6-bromopyridine
反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[OH-:9].[K+].[C:11]1([CH3:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1OCCOCCOCCOCCOCCOC1>[CH2:17]([O:9][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.
後処理
- temperatureunder reflux for 30 minutes
- washThe cool solution washed with water and brine
- dry with materialdried (MgSO4)
- customevaporated
- customto give an oil which
- distillationis vacuum-distilled (Kugelrohr)
出典と根拠
- ORDレコード
- ord-93682894d27b42bb9ad767ec95113533
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211220B1
反応ノート
読み込み中…