Sodium Sulfite → 6-Methoxynicotinic acid

HRID 324516ノート

反応式

HRID 324516 の反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][CH:4]=1.[Mn]([O-])(=O)(=O)=[O:12].[K+].S([O-])([O-])=O.[Na+].[Na+]>C(O)(C)(C)C.O>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:12])=[O:10])=[CH:5][CH:4]=1

参加物

6

反応物 3

HCID 24437Sodium SulfiteHCID 516875Potassium PermanganateHCID 33645766-Methoxypyridine-3-carbaldehyde

生成物 1

HCID 5924996-Methoxynicotinic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6386tert-Butanol溶媒

実験手順

To a solution of 6-methoxy-3-pyridinecarboxaldehyde (50 mg, 0.36 mmol; prepared according to the method of Comins and Killpack, J. Org. Chem., 1990, 55, 69-73) in t-butanol (0.5 ml) was added a solution of potassium permanganate (81 mg) in water (1.0 ml). The mixture was stirred at room temperature for two hours, and then saturated sodium sulphite solution was added until the purple colour disappeared. Reaction mixture was extracted with chloroform several times as it was gradually acidified with dilute HCl (2N). Chloroform extracts were concentrated in vacuo to yield the title compound (42 mg) as a white solid.

後処理

  1. customprepared
  2. customReaction mixture
  3. extractionwas extracted with chloroform several times as it
  4. concentrationChloroform extracts were concentrated in vacuo

出典と根拠

ORDレコード
ord-609ffab1efe6406692f63a5091ffb537
出典データセット
uspto-grants-2001_04
特許番号
US06218393B1

反応ノート

読み込み中…