Potassium Cyanide → Hydrochloric Acid

HRID 326119

反応式

HRID 326119 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:12]2[CH:13]=[N:14][CH:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1.[C-:16]#[N:17].[K+].C1OCCOC2C(=CC=CC=2)OCCOCCOC2C(=CC=CC=2)OC1>C(#N)C>[ClH:1].[ClH:1].[C:16]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:12]2[CH:13]=[N:14][CH:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1)#[N:17]

参加物

6

反応物 3

HCID 9032Potassium CyanideHCID 26541Dibenzo-18-crown-6HCID 204466765-(5-Chloropentyl)imidazo[1,5-a]pyridine

生成物 2

HCID 313Hydrochloric AcidHCID 204466655-(5-Cyanopentyl)-imidazo[1,5-a]pyridine hydrochloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 37 g of 5-(5-chloropentyl)-imidazo[1,5-a]pyridine, 21.7 g of potassium cyanide and 3 g of dibenzo-18-crown-6 in acetonitrile is heated under reflux for 20 hours. The acetonitrile is evaporated under reduced pressure, the residue is partitioned between water and methylene chloride, and the methylene chloride extract is evaporated to dryness. Treatment of a solution of the residue in ether with ethanolic hydrochloric acid yields 5-(5-cyanopentyl)-imidazo[1,5-a]pyridine hydrochloride melting at 178°-80°.

後処理

  1. temperatureunder reflux for 20 hours
  2. customThe acetonitrile is evaporated under reduced pressure
  3. customthe residue is partitioned between water and methylene chloride
  4. extractionthe methylene chloride extract
  5. customis evaporated to dryness

出典と根拠

ORDレコード
ord-82c685267c444f88a9989255cbbb1444
出典データセット
uspto-grants-1984_04
特許番号
US04444775

関連ノート

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