2,2,6,6-Tetramethyl-4-piperidone → N-(2,2,6,6-tetramethyl-4-piperidyl)-3-morpholinopropylamine

HRID 326389

反応式

HRID 326389 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][NH2:10])[CH2:3][CH2:2]1.[CH3:11][C:12]1([CH3:21])[CH2:17][C:16](=O)[CH2:15][C:14]([CH3:20])([CH3:19])[NH:13]1>CO>[CH3:11][C:12]1([CH3:21])[CH2:17][CH:16]([NH:10][CH2:9][CH2:8][CH2:7][N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH2:15][C:14]([CH3:20])([CH3:19])[NH:13]1

参加物

4

反応物 2

HCID 132202,2,6,6-Tetramethyl-4-piperidoneHCID 61055N-(3-Aminopropyl)morpholine

生成物 1

HCID 19736767N-(2,2,6,6-tetramethyl-4-piperidyl)-3-morpholinopropylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

288.4 g (2 mol) of 3-morpholinopropylamine, 310.5 g (2 mol) of 2,2,6,6-tetramethyl-4-piperidone and 300 ml of methanol are introduced into a 2 litre autoclave; 15 g of 5% Pt-on-carbon are added, and hydrogenation is carried out at 60 bar and 60° C. until the absorption of hydrogen ceases (about 15 hours).

後処理

  1. customhydrogenation is carried out at 60 bar and 60° C. until the absorption of hydrogen ceases (about 15 hours)

出典と根拠

ORDレコード
ord-da77c7797a634342bdc5c8cedae7aaa1
出典データセット
uspto-grants-1993_12
特許番号
US05268401

関連ノート

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