1,2-Dimethoxyethane → Pyridine-2,3-dicarboxamide

HRID 330362ノート

反応式

HRID 330362 の反応式
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.ClC[C:11]([N:13](CCCCCCCC)CCCCCCCC)=[O:12].C(N(C(C)C)CC)(C)C.C(COC)[O:40]C>CCCCCCC>[N:4]1[CH:5]=[CH:6][CH:7]=[C:8]([C:11]([NH2:13])=[O:12])[C:3]=1[C:2]([NH2:1])=[O:40]

参加物

6

反応物 4

HCID 80711,2-DimethoxyethaneHCID 195092-PyridinemethanamineHCID 81531DiisopropylethylamineHCID 2224152-chloro-N,N-dioctylacetamide

生成物 1

HCID 578921Pyridine-2,3-dicarboxamide

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

実験手順

Pyridine diamide 5 was prepared according to the general procedure described in Example 8 using 2-(aminomethyl)pyridine (0.019 mol), 2-chloro-N,N-dioctylacetamide (0.056 mol), diisopropylethylamine (0.056 mol) and dimethoxyethane (30 mL). The product was isolated from the heptane extraction of the acidic aqueous layer. The product was made basic by extraction with aqueous NaOH. The organic solution was concentrated, and the residue was distilled (150°-200° C., 0.10 mm).

後処理

  1. extractionThe product was made basic by extraction with aqueous NaOH
  2. concentrationThe organic solution was concentrated
  3. distillationthe residue was distilled (150°-200° C., 0.10 mm)

出典と根拠

ORDレコード
ord-c9141a8133c64220abe46a7366cd7001
出典データセット
uspto-grants-1990_01
特許番号
US04895951

反応ノート

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