反応式
CC(C)(O)[C:3]#[N:4].[NH3:7].Cl[CH2:9][CH2:10][CH2:11][C:12](=O)[CH2:13][CH2:14][CH2:15]Cl.[OH-].[Na+]>>[C:3]([C:12]12[CH2:13][CH2:14][CH2:15][N:7]1[CH2:9][CH2:10][CH2:11]2)#[N:4]参加物
5
反応条件
- 温度
- 20 °C
実験手順
To a solution of aceton cyanohydrin (2.3 g, 27 mmol) saturated with ammonia, 1,7-dichloro-4-heptanone (0.50 g, 2.7 mmol) was added dropwise at 20° C. The resulting solution was stirred for 48 hours at 20° C. under ammonia gas atmosphere. To the reaction mixture, 0.1N-NaOH was added to extract with methylene chloride. The extract was dried over anhydrous sodium sulfate, concentrated and distilled in vacuo to afford 0.33 g of the desired compound (Yield: 89%).
後処理
- extractionto extract with methylene chloride
- dry with materialThe extract was dried over anhydrous sodium sulfate
- concentrationconcentrated
- distillationdistilled in vacuo
出典と根拠
- ORDレコード
- ord-a85465a5215648fdaf2a095d239f17e5
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04897495
関連ノート
読み込み中…