Water → 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne
反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][OH:8].Br[CH2:10][C:11]#[CH:12].O>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:12][C:11]#[CH:10]参加物
5
実験手順
To a solution of 2 g 2-(2-Methoxy-ethoxy)-ethanol in 20 ml THF 1.8 g KOt-Bu were added at 0° C. After stirring for 10 min 8.1 ml 3-Bromo-propyne (75% in toluene) were added and the mixture was warmed to RT and stirred for 4 h. Then 10 ml of water were added and the mixture was filtered through a chem elut® cartridge by elution with CHCl3. This solution containing the desired product was subjected to the next reaction step.
後処理
- additionwere added
- filtrationthe mixture was filtered through a chem elut® cartridge by elution with CHCl3
- additionThis solution containing the desired product
- customwas subjected to the next reaction step
出典と根拠
- ORDレコード
- ord-d90fa2892b694c848f6f1ca5bfd7cdec
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429581B2
反応ノート
読み込み中…