Water → 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

HRID 33264

反応式

HRID 33264 の反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][OH:8].Br[CH2:10][C:11]#[CH:12].O>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:12][C:11]#[CH:10]

参加物

5

反応物 3

HCID 962WaterHCID 7842Propargyl bromideHCID 8134Diethylene Glycol Monomethyl Ether

生成物 1

HCID 183816833-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2 g 2-(2-Methoxy-ethoxy)-ethanol in 20 ml THF 1.8 g KOt-Bu were added at 0° C. After stirring for 10 min 8.1 ml 3-Bromo-propyne (75% in toluene) were added and the mixture was warmed to RT and stirred for 4 h. Then 10 ml of water were added and the mixture was filtered through a chem elut® cartridge by elution with CHCl3. This solution containing the desired product was subjected to the next reaction step.

後処理

  1. additionwere added
  2. filtrationthe mixture was filtered through a chem elut® cartridge by elution with CHCl3
  3. additionThis solution containing the desired product
  4. customwas subjected to the next reaction step

出典と根拠

ORDレコード
ord-d90fa2892b694c848f6f1ca5bfd7cdec
出典データセット
uspto-grants-2008_09
特許番号
US07429581B2

関連ノート

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