1,1'-Carbonyldiimidazole → Imidazole-1-carboxylic acid (4-pyrrolidin-1-yl-butyl)-amide

HRID 335519

反応式

HRID 335519 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][NH2:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:11](N1C=CN=C1)([N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:12]>O1CCCC1>[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[O:12])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 27627624-(Pyrrolidin-1-yl)butan-1-amine

生成物 1

HCID 57552584Imidazole-1-carboxylic acid (4-pyrrolidin-1-yl-butyl)-amide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

In a flask under nitrogen, 4-Pyrrolidin-1-yl-butylamine (1.3 equiv, 10.1 g) was taken up in tetrahydrofuran (105 mL, 5 volumes). The mixture was cooled to 0° C. and 1,1′-carbonyldiimidazole (1.3 equiv, 11.6 g) was added. The mixture stirred at 0° C. for 20 minutes, then warmed to 20° C. over 10 minutes and held at 20° C. for 30 minutes.

後処理

  1. temperaturewarmed to 20° C. over 10 minutes
  2. waitheld at 20° C. for 30 minutes

出典と根拠

ORDレコード
ord-fd652d6a940c4feba76e780d02922705
出典データセット
uspto-grants-2014_11
特許番号
US08884025B2

関連ノート

読み込み中…