Pyridine → 2-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester

HRID 341809

反応式

HRID 341809 の反応式
[F:1][C:2]([F:15])([F:14])[S:3]([O:6]S(C(F)(F)F)(=O)=O)(=[O:5])=[O:4].C[CH:17](O)[C:18]([O-:20])=[O:19].N1C=CC=C[CH:23]=1>C(Cl)Cl>[S:3]([O:6][CH2:17][C:18]([O:20][CH3:23])=[O:19])([C:2]([F:15])([F:14])[F:1])(=[O:5])=[O:4]

参加物

5

反応物 3

HCID 1049PyridineHCID 67749Trifluoromethanesulfonic anhydrideHCID 91435Lactate

生成物 1

HCID 112297732-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester収率 90%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

10.09 ml (60 mmol) trifluorometansulfonic anhydrid dissolved in CH2Cl2 was added dropwise to a mixture of 4.05 ml (50 mmol) methylglycolate and 4.04 ml (50 mmol) pyridin in CH2Cl2 (totally 62.5 ml) at 0° C. during 25 minutes, and thereafter stirred at 0° C. for 1 H. After washing with 0.3M KHSO4 and saturated NA2CO3, drying (Na2SO4) and filtration, evaporation of the solvent in vacuo gave 9.94 g (90%) of the title compound.

後処理

  1. washAfter washing with 0.3M KHSO4 and saturated NA2CO3
  2. customdrying
  3. filtration(Na2SO4) and filtration, evaporation of the solvent in vacuo

出典と根拠

ORDレコード
ord-ed848f084cb34979af6207996e646ec0
出典データセット
uspto-grants-1999_01
特許番号
US05856307

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