Pyridine → 4-(Trifluoromethyl)cinnamoyl chloride

HRID 342613

反応式

HRID 342613 の反応式
S(Cl)([Cl:3])=O.[F:5][C:6]([F:19])([F:18])[C:7]1[CH:17]=[CH:16][C:10](/[CH:11]=[CH:12]/[C:13](O)=[O:14])=[CH:9][CH:8]=1.N1C=CC=CC=1>C(Cl)Cl>[F:5][C:6]([F:19])([F:18])[C:7]1[CH:17]=[CH:16][C:10](/[CH:11]=[CH:12]/[C:13]([Cl:3])=[O:14])=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 6880704-(Trifluoromethyl)cinnamic acid

生成物 1

HCID 111072914-(Trifluoromethyl)cinnamoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Thionyl chloride (335 ml, 4.6 mmol) was added at 0° C. to 4-trifluoromethyl-E-cinnamic acid (1 g, 4.6 mmol) and pyridine (375 ml, 4.6 mmol) in dry CH2Cl2. The mixture was then stirred for 1 h without cooling, again cooled to 0° C. and filtered with the exclusion of moisture. The filtrate (10 ml) contained the title compound and was used in aliquots for the next reaction step.

後処理

  1. temperaturewithout cooling
  2. filtrationfiltered with the exclusion of moisture
  3. customwas used in aliquots for the next reaction step

出典と根拠

ORDレコード
ord-548f034edc534529847ea7bcc3e082ba
出典データセット
uspto-grants-1999_01
特許番号
US05859025

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