Iodoethane → HCID 12515028、化合物

HRID 342715

反応式

HRID 342715 の反応式
COCCCCCCCCCCC[C:14]([NH:16][C@@H:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH3:18])=[O:15].[C:24]([O:28]C(N[C@@H](C(O)=O)C)=O)([CH3:27])([CH3:26])[CH3:25].O.O.O.O.O.[OH-].C[N+](C)(C)C.C(I)C>C(#N)C>[C:24]([O:28][C:14]([NH:16][C@@H:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH3:18])=[O:15])([CH3:27])([CH3:26])[CH3:25]

参加物

6

反応物 4

HCID 6340IodoethaneHCID 82620Tetramethylammonium Hydroxide PentahydrateHCID 637606BOC-D-alanineHCID 15870267HCID 15870267、化合物

生成物 1

HCID 12515028HCID 12515028、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Reaction Scheme 6 illustratively shows the preparation of N-(12-methoxy-1-oxododecyl)-D-alanine, ethyl ester wherein N-(t-butyloxycarbonyl)-D-alanine (16) is treated with tetramethylammonium hydroxide pentahydrate in acetonitrile followed by the addition of ethyl iodide to form N-(t-butyloxycarbonyl)-D-alanine, ethyl ester (17) which in turn reacts with trifluoroacetic acid in methylene chloride to give the trifluoroacetate salt of D-alanine ethyl ester (18) which, when treated with 2-methoxydodecanoyl chloride (9) in methylene chloride, gives the desired fatty acid amino ester (19).

後処理

  1. customReaction Scheme 6

出典と根拠

ORDレコード
ord-c9943100722e477b81ddb31f495ec7d2
出典データセット
uspto-grants-1999_01
特許番号
US05859052

関連ノート

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