Pyridine → 2-(3-Chloropropyl)-6-methylphenol
反応式
O[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[OH:12].N1C=CC=CC=1.S(Cl)([Cl:21])=O>O1CCCC1.CN(C)C=O>[Cl:21][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[OH:12]参加物
6
反応条件
- 温度
- 60 °C
実験手順
To a solution of 2-(3-hydroxypropyl)-6-methylphenol (3.0 g) in tetrahydrofuran (30 mL) were added pyridine (730 μL), thionyl chloride (2 mL) and one drop of N,N-dimethylformamide. After stirring at 60° C. for 2 hours, the reaction mixture was evaporated, and then diethyl ether was added to the residue. The resulting solution was washed with distilled water and brine, dried over anhydrous magnesium sulfate and evaporated in vacuo to give the title compound in quantitative yield.
後処理
- customthe reaction mixture was evaporated
- additiondiethyl ether was added to the residue
- washThe resulting solution was washed with distilled water and brine
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-d12eb7ad3b8d4622b4cc040d6ed8f77d
- 出典データセット
- uspto-grants-1999_01
- 特許番号
- US05861437
反応ノート
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