Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane

HRID 345816

反応式

HRID 345816 の反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH2:12])[CH3:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH:12][C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH3:11]

参加物

6

反応物 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 936582,2-Dimethoxy-1-methylethylamine

生成物 1

HCID 15069987N-(1,1-dimethoxyprop-2-yl)urethane

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K2CO3. The solution is concentrated and the residue is distilled.

後処理

  1. customthe organic phase is separated off
  2. extractionthe aqueous phase is extracted with toluene
  3. dry with materialthe toluene solutions are dried over K2CO3
  4. concentrationThe solution is concentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-ae41be02a0814be8befcd23c5a66691d
出典データセット
uspto-grants-1991_10
特許番号
US05059597

関連ノート

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