Thionyl Chloride → 4-Oxo-3-thiazolidinylacetyl chloride

HRID 34907

反応式

HRID 34907 の反応式
S(Cl)([Cl:3])=O.[O:5]=[C:6]1[CH2:10][S:9][CH2:8][N:7]1[CH2:11][C:12]([OH:14])=O>ClCCl.O1CCCC1>[O:5]=[C:6]1[CH2:10][S:9][CH2:8][N:7]1[CH2:11][C:12]([Cl:3])=[O:14]

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 51472572-(4-Oxo-1,3-thiazolidin-3-yl)acetic acid

生成物 1

HCID 212972254-Oxo-3-thiazolidinylacetyl chloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Thionyl chloride (2.00 ml) was added dropwise to a solution of 4-oxo-3-thiazolidinylacetic acid (1.60 g) in a mixture of dichloromethane (20 ml) and tetrahydrofuran (5.0 ml) at room temperature. After the mixture was stirred for 5 hours at the same temperature, the solvent was evaporated in vacuo to give 4-oxo-3-thiazolidinylacetyl chloride (1.78 g) as brown semisolid.

後処理

  1. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-566cc7d4e2bc48d4b9bbc4f953cfff39
出典データセット
uspto-grants-1988_08
特許番号
US04764514

関連ノート

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