Acetone → 3-Piperidinopropiophenone hydrochloride

HRID 35011

反応式

HRID 35011 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[ClH:10].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C=O.[CH3:19]C(C)=O>C(O)C>[ClH:10].[N:11]1([CH2:19][CH2:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

6

反応物 4

HCID 180AcetoneHCID 712FormaldehydeHCID 7410AcetophenoneHCID 2723721Piperidine, hydrochloride (1:1)

生成物 1

HCID 701713-Piperidinopropiophenone hydrochloride収率 75.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 120 g of acetophenone, 133 g of piperidine hydrochloride and 50 g of paraformaldehyde in 120 ml of ethanol was refluxed for 6 hours. The mixture was then allowed to stand for cooling to soldify. The resulting solid was crushed after addition of 400 ml of acetone, and then collected by filtration. The collected solid was washed successively with acetone and hexane and dried to obtain 191.6 g (yield: 75.4%) of the subject compound as a white scaly product.

後処理

  1. temperaturewas refluxed for 6 hours
  2. temperaturefor cooling
  3. customThe resulting solid was crushed
  4. filtrationcollected by filtration
  5. washThe collected solid was washed successively with acetone and hexane
  6. customdried

出典と根拠

ORDレコード
ord-2a8bdce2894f4e98a5de81fcefcaeafc
出典データセット
uspto-grants-1988_08
特許番号
US04764617

関連ノート

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