Acetone → 3-Piperidinopropiophenone hydrochloride
反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[ClH:10].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C=O.[CH3:19]C(C)=O>C(O)C>[ClH:10].[N:11]1([CH2:19][CH2:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1参加物
6
実験手順
A mixture of 120 g of acetophenone, 133 g of piperidine hydrochloride and 50 g of paraformaldehyde in 120 ml of ethanol was refluxed for 6 hours. The mixture was then allowed to stand for cooling to soldify. The resulting solid was crushed after addition of 400 ml of acetone, and then collected by filtration. The collected solid was washed successively with acetone and hexane and dried to obtain 191.6 g (yield: 75.4%) of the subject compound as a white scaly product.
後処理
- temperaturewas refluxed for 6 hours
- temperaturefor cooling
- customThe resulting solid was crushed
- filtrationcollected by filtration
- washThe collected solid was washed successively with acetone and hexane
- customdried
出典と根拠
- ORDレコード
- ord-2a8bdce2894f4e98a5de81fcefcaeafc
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04764617
反応ノート
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