Hydrochloric Acid → 3-(Dimethylamino)-1-phenyl-1-propanone

HRID 353649

反応式

HRID 353649 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].Cl.[CH3:11][NH:12][CH3:13].O1CCO[CH2:15]1.Cl>>[CH3:11][N:12]([CH3:15])[CH2:13][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 7410AcetophenoneHCID 10473Dimethylamine, hydrochlorideHCID 125861,3-Dioxolane

生成物 1

HCID 770423-(Dimethylamino)-1-phenyl-1-propanone

反応条件

温度
0 °C

実験手順

30.0 g of acetophenone are mixed with 24.5 g of dimethylamine hydrochloride and 74.1 g of 1,3-dioxolane, 2.5 g of concentrated hydrochloric acid are added, and the mixture is heated to exactly 90° C. and maintained at that temperature for 3.5 hours. Excess dioxolane is distilled off and the residue is cooled to 0° C. The resulting 3-dimethylamino-1-phenylpropan-1-one of formula

後処理

  1. additionare added
  2. temperaturethe mixture is heated to exactly 90° C.
  3. temperaturemaintained at that temperature for 3.5 hours
  4. distillationExcess dioxolane is distilled off

出典と根拠

ORDレコード
ord-b264f027321045e58b8d03c1d1db12ab
出典データセット
uspto-grants-2004_06
特許番号
US06753451B2

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