Hydrochloric Acid → 3-(Dimethylamino)-1-phenyl-1-propanone
反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].Cl.[CH3:11][NH:12][CH3:13].O1CCO[CH2:15]1.Cl>>[CH3:11][N:12]([CH3:15])[CH2:13][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]参加物
5
反応条件
- 温度
- 0 °C
実験手順
30.0 g of acetophenone are mixed with 24.5 g of dimethylamine hydrochloride and 74.1 g of 1,3-dioxolane, 2.5 g of concentrated hydrochloric acid are added, and the mixture is heated to exactly 90° C. and maintained at that temperature for 3.5 hours. Excess dioxolane is distilled off and the residue is cooled to 0° C. The resulting 3-dimethylamino-1-phenylpropan-1-one of formula
後処理
- additionare added
- temperaturethe mixture is heated to exactly 90° C.
- temperaturemaintained at that temperature for 3.5 hours
- distillationExcess dioxolane is distilled off
出典と根拠
- ORDレコード
- ord-b264f027321045e58b8d03c1d1db12ab
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06753451B2
反応ノート
読み込み中…