U 99363 → 4-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine

HRID 361813

反応式

HRID 361813 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:24])[C:15]2[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:24][N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1

参加物

5

反応物 2

HCID 133107U 99363HCID 2723923Ammonium formate

生成物 1

HCID 108473684-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 1-benzyl-4-[N-methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine (EXAMPLE 70, 1.40 g), palladium-on-carbon (10%, 1.4 g) and ammonium formate (813 mg) in methanol (25 ml) is degassed, stirred at 65° for 45 min, cooled to 20°-25°, and filtered to remove catalyst. The filtrate is concentrated under reduced pressure to give the title compound, NMR (CDCl3) 7.83, 6.97, 6.71, 4.02, 3.88, 3.15, 2.88, 2.63, 1.75 and 1.46δ.

後処理

  1. customis degassed
  2. temperaturecooled to 20°-25°
  3. filtrationfiltered
  4. customto remove catalyst
  5. concentrationThe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4794e628ec764be1bb45fce4998378a0
出典データセット
uspto-grants-1999_02
特許番号
US05866589

関連ノート

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