Methyl iodide → 1-(1-Methyl-1H-indol-3-yl)ethanone

HRID 362791

反応式

HRID 362791 の反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)(=[O:3])[CH3:2].[H-].[Na+].[CH3:15]I>C1COCC1>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH3:15])[CH:5]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 128023-AcetylindoleHCID 24758Sodium hydride

生成物 1

HCID 5941561-(1-Methyl-1H-indol-3-yl)ethanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3-Acetyl-1H-indole (4.00 g, 0.025 mol) was dissolved in dry THF (100 ml), and treated with 80% sodium hydride (0.794 g, 0.0263 mol) with stirring under Ar. After 0.5 h, methyl iodide (2.36 ml, 0.038 mol) was added. After 20 h, the reaction mixture was evaporated under reduced pressure and the residue partitioned between ethyl acetate and water. The organic layer was then dried (Na2SO4), and evaporated under reduced pressure to give the title compound as a pale brown oil which crystallised on standing (4.20 g, 97%).

後処理

  1. waitAfter 20 h
  2. customthe reaction mixture was evaporated under reduced pressure
  3. customthe residue partitioned between ethyl acetate and water
  4. dry with materialThe organic layer was then dried (Na2SO4)
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-91a523413b884541b67862091b944cc1
出典データセット
uspto-grants-1999_02
特許番号
US05872134

関連ノート

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