Sulfuric Acid → N-tert-butylpyrazine-2-carboxamide

HRID 3646

反応式

HRID 3646 の反応式
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][CH:6]=[CH:5][N:4]=1)#[N:2].[CH3:11][C:12](=[CH2:14])[CH3:13].S(=O)(=O)(O)[OH:16]>C(O)(C)(C)C>[C:12]([NH:10][C:9]([C:8]1[CH:3]=[N:4][CH:5]=[CH:6][N:7]=1)=[O:16])([CH3:13])([CH3:11])[CH3:14].[C:9]([C:8]1[C:3]([C:1]([NH:2][C:12]([CH3:13])([CH3:11])[CH3:14])=[O:16])=[N:4][CH:5]=[CH:6][N:7]=1)#[N:10]

参加物

6

反応物 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 3005142,3-Dicyanopyrazine

生成物 2

HCID 4462842N-tert-butylpyrazine-2-carboxamideHCID 542094853-cyano-N-tert-butyl-2-pyrazinecarboxamide

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

A compound having the formula (4) can be obtained as follows. The corresponding 2, 3-dicyano-pyrazine is reacted with tert-butyl alcohol or isobutylene in the presence of sulfuric acid to obtain the corresponding N-tert-butyl-2-pyrazinecarboxamide and/or 3-cyano-N-tert-butyl-2-pyrazinecarboxamide. Then, thus obtained corresponding N-tert-butyl-2-pyrazinecarboxamide and/or 3-cyano-N-tert-butyl-2-pyrazinecarboxamide are hydrolyzed under an alkaline condition.

後処理

  1. customcan be obtained

出典と根拠

ORDレコード
ord-db920a7cf3b74cdbbcd3ab9ee72edff5
出典データセット
uspto-grants-1998_03
特許番号
US05734055

関連ノート

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