Sodium hydride → 5-Benzyloxy-1-[3-(3-bromopyridin-4-yl)propyl]-3-(4-methylthiazol-2-yl)-1H-pyridin-2-one

HRID 367006ノート

反応式

HRID 367006 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]2[S:17][CH:18]=[C:19]([CH3:21])[N:20]=2)[C:12](=[O:15])[NH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[Br-].[Li+].Br[CH2:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][N:33]=[CH:32][C:31]=1[Br:36]>CN(C=O)C.COCCOC>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]2[S:17][CH:18]=[C:19]([CH3:21])[N:20]=2)[C:12](=[O:15])[N:13]([CH2:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][N:33]=[CH:32][C:31]=2[Br:36])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 24758Sodium hydrideHCID 82050Lithium BromideHCID 110332153-Bromo-4-(3-bromopropyl)pyridineHCID 1354930145-Benzyloxy-3-(4-methylthiazol-2-yl)-1H-pyridin-2-one

生成物 1

HCID 109946665-Benzyloxy-1-[3-(3-bromopyridin-4-yl)propyl]-3-(4-methylthiazol-2-yl)-1H-pyridin-2-one収率 83%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 80711,2-Dimethoxyethane溶媒2 回

反応条件

温度
0 °C

実験手順

Prepared by a modification of the procedure reported in Tetrahedron Lett., 1995, 8917. 5-Benzyloxy-3-(4-methylthiazol-2-yl)-1H-pyridin-2-one (3.3 mmol) was dissolved in DMF (5 ml) and DME (20 ml). The reaction mixture was cooled to 0° C. and treated with sodium hydride (3.5 mmol). After 10 min, the reaction mixture was treated with lithium bromide (6.6 mmol) and stirred for 15 min at room temperature. The reaction mixture was treated with a solution of 4-(3-bromopropyl)-3-bromopyridine (5.0 mmol) in DME (5 ml) and then it was heated at 75° C. for 60 h. The reaction mixture was cooled, acidified, and washed with ethyl acetate. The aqueous layer was basified and extracted with ethyl acetate. The organic extracts were dried (MgSO4), filtered, and evaporated in vacuo. Purification by column chromatography gave the product as a yellow foam (2.74 mmol, 82%). δH (250 MHz; CDCl3) 8.65 (1H, s), 8.60 (1H, brd), 8.41 (1H, d, J=7.1), 7.40-7.33 (5H, m), 7.16 (1H, d, J=7.3), 7.03 (1H, s), 7.00 (1H, d, J=4.6), 5.02 (2H, s), 4.13 (2H, t, J=10.4), 2.79-2.72 (2H, m), 2.53 (3H, s), 2.17-2.04 (2H, m).

後処理

  1. customPrepared by a modification of the procedure
  2. temperatureit was heated at 75° C. for 60 h
  3. temperatureThe reaction mixture was cooled
  4. washwashed with ethyl acetate
  5. extractionextracted with ethyl acetate
  6. dry with materialThe organic extracts were dried (MgSO4)
  7. filtrationfiltered
  8. customevaporated in vacuo
  9. customPurification by column chromatography

出典と根拠

ORDレコード
ord-158ca0bc81f541e7ba4172bd3a2521cf
出典データセット
uspto-grants-2000_10
特許番号
US06133255

反応ノート

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