Water → (R)-2-phenyl-1,2-propanediol

HRID 37020

反応式

HRID 37020 の反応式
C([O-])([O-])=[O:2].[K+].[K+].[OH2:7].[CH3:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[CH2:10]>O=[Os](=O)(=O)=O.[Pt].CC(O)(C)C>[C:11]1([C@:9]([OH:2])([CH3:8])[CH2:10][OH:7])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

7

反応物 3

HCID 962WaterHCID 7407Alpha-MethylstyreneHCID 11430Potassium Carbonate

生成物 1

HCID 6951538(R)-2-phenyl-1,2-propanediol

試薬・触媒・溶媒 3

HCID 23939Platinum触媒HCID 30318Osmium Tetroxide触媒HCID 6386tert-Butanol溶媒

実験手順

A divided glass H-cell, as described in example 6.1 but smaller in size (50 ml in anode and cathode compartment), is charged in the cathode with 40 mL, 5% H3Po4 solution and in the anode with K2CO3 (4.1 g, 30 mmol), H2O (25 mL), t-BuOH (25 mL), chiral ligand, PHAL-DHQD (390 mg, 0.5 mmol), OsO4 (0.196M in toluene, 2.6 mL, 0.5 mmol) and finally α-methylstyrene (1.2 g, 10 mmol). The mixture is electrolyzed at 20° C. and 0.5 V (vs Ag/AgCl) working potential using platinum foils as the anode and cathode. After ca. 2000 coulombs of electricity is consumed, the reaction is worked up as Example 6.7 to give (R)-2-phenyl-1.2-propanediol in good yield.

後処理

  1. customis electrolyzed at 20° C.
  2. customAfter ca. 2000 coulombs of electricity is consumed

出典と根拠

ORDレコード
ord-9d400f28fed1457783e933c212b06015
出典データセット
uspto-grants-1995_05
特許番号
US05419817

関連ノート

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