Dimethylhydantoin → Nilutamide

HRID 374125

反応式

HRID 374125 の反応式
[CH3:1][C:2]1([CH3:9])[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[N+:10]([C:13]1[CH:18]=[CH:17][C:16](Cl)=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21])([O-:12])=[O:11]>C(O)C.[Cu]>[F:21][C:20]([F:22])([F:23])[C:14]1[CH:15]=[C:16]([N:4]2[C:3](=[O:8])[C:2]([CH3:9])([CH3:1])[NH:6][C:5]2=[O:7])[CH:17]=[CH:18][C:13]=1[N+:10]([O-:12])=[O:11]

参加物

5

反応物 2

HCID 6491DimethylhydantoinHCID 670525-Chloro-2-nitrobenzotrifluoride

生成物 1

HCID 4493Nilutamide

試薬・触媒・溶媒 2

HCID 23978Copper触媒HCID 702Ethanol溶媒2 回

反応条件

温度
200 °C

実験手順

71.5 grams of copper in powder form were added to 96.10 grams of 5,5-dimethyl-hydantoin and 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene. The mixture was heated to 200° C. for about 21 hours, the pressure being maintained at 450 millibars, then, was cooled to 20° C. and taken up in 480 ml of ethanol. The product was characterized and determined by thin layer chromatography of the ethanol solution.

後処理

  1. temperaturethe pressure being maintained at 450 millibars
  2. temperaturewas cooled to 20° C.

出典と根拠

ORDレコード
ord-f33c2a567db743aeaaf8f1ed8c025a89
出典データセット
uspto-grants-1992_11
特許番号
US05166358

関連ノート

読み込み中…