Pyridine → 2-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoyl chloride

HRID 374961ノート

反応式

HRID 374961 の反応式
[CH3:1][C:2]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:7]=1[C:8](O)=[O:9])([CH3:4])[CH3:3].N1C=CC=CC=1.C(Cl)(=O)C([Cl:25])=O>C(#N)C>[CH3:1][C:2]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:7]=1[C:8]([Cl:25])=[O:9])([CH3:4])[CH3:3]

参加物

5

反応物 3

HCID 1049PyridineHCID 65578Oxalyl chlorideHCID 189963762-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoic acid

生成物 1

HCID 189963812-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoyl chloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-[(1,1-dimethylethyl)oxy]-6-chlorobenzoic acid (68.6 mg, 0.3 mmol) was weighed into a 1 dram septum-capped vial containing a micro stir bar under nitrogen. Dry acetonitrile (300 microliter), dry pyridine (24 microliter, 0.3 mmol) and oxalyl chloride (26 microliter, 0.3 mmol) were added in order to the vial using microliter syringes. The yellow homogeneous solution was stirred for 30 minutes to afford a solution of 2-[(1,1-dimethylethyl)oxy]-6-chlorobenzoyl chloride.

後処理

  1. customseptum-capped vial
  2. additioncontaining a micro stir bar under nitrogen

出典と根拠

ORDレコード
ord-8b539eb3fffa421bbe814e73e4d9a995
出典データセット
uspto-grants-1996_01
特許番号
US05482974

反応ノート

読み込み中…