Ammonium formate → N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

HRID 379474

反応式

HRID 379474 の反応式
[CH3:1][N:2]([CH2:11][CH:12]([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH:18]([C:21]([C:23]2[N:27]([CH2:28][C:29]3[N:30](CC4C=CC=CC=4)[CH:31]=[CH:32][N:33]=3)[C:26]3[CH:41]=[CH:42][CH:43]=[CH:44][C:25]=3[N:24]=2)=[O:22])[CH2:17][CH2:16]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][N:2]([CH2:11][CH:12]([C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1)[CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][CH:18]([C:21]([C:23]2[N:27]([CH2:28][C:29]3[NH:33][CH:32]=[CH:31][N:30]=3)[C:26]3[CH:41]=[CH:42][CH:43]=[CH:44][C:25]=3[N:24]=2)=[O:22])[CH2:19][CH2:20]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 21697470N-methyl-N-(4-(4-(1-(1-benzylimidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

生成物 1

HCID 21697366N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Combine N-methyl-N-(4-(4-(1-(1-benzylimidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide (5 mmol) and 10% palladium-on-carbon (1.5 g) in methanol (50 mL). Add anhydrous ammonium formate (25 mmol). Heat to reflux. After 18 hours, filter, rinse with dichloromethane, and evaporate the filtrate in vacuo to give the title compound.

後処理

  1. temperatureHeat to reflux
  2. filtrationfilter
  3. washrinse with dichloromethane
  4. customevaporate the filtrate in vacuo

出典と根拠

ORDレコード
ord-7caf438962724a72873b633243986422
出典データセット
uspto-grants-2001_10
特許番号
US06297259B1

関連ノート

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