Iodoethane → Tert-butyl 5-bromopyridin-2-YL(ethyl)carbamate

HRID 391079ノート

反応式

HRID 391079 の反応式
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[H-].[Na+].I[CH2:19][CH3:20]>C1COCC1>[C:4]([O:3][C:1](=[O:2])[N:8]([C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)[CH2:19][CH3:20])([CH3:7])([CH3:6])[CH3:5]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 162178432-(Boc-amino)-5-bromopyridine

生成物 1

HCID 53217453Tert-butyl 5-bromopyridin-2-YL(ethyl)carbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-(BOC-amino)-5-bromopyridine (500 mg) in THF (20 mL) at 0° C. was added sodium hydride (88 mg) and the reaction stirred for 20 min. Then, iodoethane (0.18 mL) was added and the reaction stirred at room temperature for 16 h. The reaction was quenched with water (20 mL) and extracted into ethylacetate (3×20 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester as a white solid.

後処理

  1. stirringthe reaction stirred at room temperature for 16 h
  2. customThe reaction was quenched with water (20 mL)
  3. extractionextracted into ethylacetate (3×20 mL)
  4. dry with materialThe organic layers were dried (MgSO4)

出典と根拠

ORDレコード
ord-439df2aa11e04bd2b1c54ff44cb1a47a
出典データセット
uspto-grants-2013_02
特許番号
US08383620B2

反応ノート

読み込み中…