Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

HRID 39224

反応式

HRID 39224 の反応式
[C:1]([C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[S:10](Cl)(=[O:12])=[O:11])#[N:2].[S:14]1[CH2:18][CH2:17][NH:16][CH2:15]1>O1CCCC1>[F:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([S:10]([N:16]2[CH2:17][CH2:18][S:14][CH2:15]2)(=[O:12])=[O:11])[C:3]=1[C:1]#[N:2]

参加物

4

反応物 2

HCID 10444ThiazolidineHCID 205052122-Cyano-3-fluorobenzene-1-sulfonyl chloride

生成物 1

HCID 442186552-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.

後処理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customPurification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
  3. washby acidic washing with a 1M HCl solution

出典と根拠

ORDレコード
ord-62d17e228e394a5fafc800d9e62ffeab
出典データセット
uspto-grants-2013_09
特許番号
US08524896B2

関連ノート

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