Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile
反応式
[C:1]([C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[S:10](Cl)(=[O:12])=[O:11])#[N:2].[S:14]1[CH2:18][CH2:17][NH:16][CH2:15]1>O1CCCC1>[F:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([S:10]([N:16]2[CH2:17][CH2:18][S:14][CH2:15]2)(=[O:12])=[O:11])[C:3]=1[C:1]#[N:2]参加物
4
実験手順
440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.
後処理
- concentrationThe reaction mixture is concentrated in vacuo
- customPurification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
- washby acidic washing with a 1M HCl solution
出典と根拠
- ORDレコード
- ord-62d17e228e394a5fafc800d9e62ffeab
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524896B2
反応ノート
読み込み中…