8-Methylquinoline → Quinoline, 8-methyl-, 1-oxide

HRID 39733

反応式

HRID 39733 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.ClC1C=CC=C(C(OO)=[O:20])C=1.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N+:10]([O-:20])=[CH:9][CH:8]=[CH:7]2

参加物

5

反応物 3

HCID 119108-MethylquinolineHCID 70297m-Chloroperbenzoic acid2 回HCID 516892Sodium Bicarbonate

生成物 1

HCID 12488418Quinoline, 8-methyl-, 1-oxide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 40 mL of a chloroform solution containing 2.0 g of 8-methylquinoline, 3.6 g of m-chloroperbenzoic acid was added, and the mixture was stirred at room temperature overnight. Thereto was added 1.0 g of m-chloroperbenzoic acid, and the mixture was stirred at room temperature overnight. An aqueous saturated sodium hydrogen carbonate solution was added to the reaction mixture, the organic layer was separated, and the aqueous layer was extracted with chloroform. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 2.2 g of a brown oily substance, 8-methylquinoline N-oxide.

後処理

  1. additionwas added
  2. stirringthe mixture was stirred at room temperature overnight
  3. customthe organic layer was separated
  4. extractionthe aqueous layer was extracted with chloroform
  5. washthe resultant solution was washed with an aqueous saturated sodium chloride solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-6ad15f2d3e544c06b2ee4d550dd2382c
出典データセット
uspto-grants-2013_09
特許番号
US08524738B2

関連ノート

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