(+-)-Pantolactone → Keto-pantoyllactone

HRID 399615

反応式

HRID 399615 の反応式
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1.ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O>CC1(C)N([O])C(C)(C)CCC1>[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1

参加物

4

反応物 2

HCID 989(+-)-PantolactoneHCID 6909Trichloroisocyanuric Acid

生成物 1

HCID 39Keto-pantoyllactone収率 93.5%

試薬・触媒・溶媒 1

HCID 2724126Tempo触媒

実験手順

5 g (38.4 mmol) of pantolactone were reacted with 3.6 g (15.5 mmol) of trichloroisocyanuric acid as described in Example 13. In contrast to Example 13, 60 mg (0.25 mmol) of TEMPO derivative C were used as the catalyst. The reaction had finished after 3 hours. After recrystallization of the crude product there were obtained 4.6 g (93%) of ketopantolactone, m.p. 69°-70° C., GC content: 100% (area percent).

後処理

  1. customAfter recrystallization of the crude product

出典と根拠

ORDレコード
ord-05d2bc7a176a47628cfe714f094b364a
出典データセット
uspto-grants-1998_10
特許番号
US05821374

関連ノート

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